http://localhost:8080/xmlui/handle/123456789/10 2026-04-05T19:55:59Z 2026-04-05T19:55:59Z GAMDE, Solomon Mathias MICHELLE, Ogidiagba Stephanie ABRIBA, Simon Peter http://localhost:8080/xmlui/handle/123456789/2997 2025-06-13T12:04:31Z 2024-07-01T00:00:00Z

Decoding the Natural Killer Cell Enigma: A Review GAMDE, Solomon Mathias; MICHELLE, Ogidiagba Stephanie; ABRIBA, Simon Peter Background: While the liver’s hepatocytes and Kupffer cells are prominent foci of study, the distinct and relatively uncharted roles played by the natural killer cells in liver immunity provide fertile ground for exploration. In this review paper, we have tried to uncover the unique phenotypic and functional attributes of liver-resident natural killer cells, consequently establishing a profound connection between liver immunology and histopathology. Objective: This review aims to provide an overview of the phenotypic and functional properties of the liver-resident natural killer cells, giving insight on the immunological and histological repercussions of their interactions during liver infections, inflammation, and hepatocellular cancer. Methods: In this review, published papers in electronic databases comprising PubMed, Scopus, and Google Scholar were retrieved using search themes such as immunological cells, natural killer cell, liver inflammation, and liver cell were examined. Results: The liver-resident natural killer cells are potent producers of cytokines, including interferon-gamma (IFN-γ) and modulate the phenotype and function of hepatic macrophages, enhancing their antimicrobial activity, as well as influence the activation and cytotoxic function of CD8+ T cells, particularly during chronic liver inflammation. Conclusion: Our review underscores the undeniable significance of the natural killer cells in the liver defence and highlighted the challenges and constraints researchers encounter when studying the liver natural killer cells. Continued research endeavour are necessary to harness the full capabilities of the natural killer cells, ultimately leading to better insights, innovative therapies, and enhanced protection for the liver, and by extension, the entire body.

2024-07-01T00:00:00Z Abriba, Simon P. Gamde M. S., Solomom M. http://localhost:8080/xmlui/handle/123456789/2772 2024-09-12T13:08:55Z 2024-07-03T00:00:00Z

Knowledge of Cervical Cancer among Femal in North Central Nigeria Abriba, Simon P.; Gamde M. S., Solomom M. Background: Cervical cancer is a major cause of mortality among women of reproductive age group despite several measures initiated to halt the disease. Organized cytology-based screening is an effective technique in reducing the incidence and mortality of the disease. However, some women do not know what the screening is for. This study examined the knowledge on cervical cancer among women in North Central Nigeria. Method: This cross-sectional study was carried out on 242 females of age group 15 -55 years using an explorative structured questionnaire-base method from October - December 2023. Statistical Package for the Social Sciences (SPSS) version 26 was used for analysis. Results: The study found that 76.9% of the study population had never gone for cervical screening and the majority who are willing (60.2%) do not know when and where to get a screening test. The access to cervical cancer screening services is a major difficulty in the community. In addition, majority (93.8%) participants who held a higher education certificate or were currently pursuing an undergraduate degree, lack a clear understanding of the risk factors of cervical cancer and HPV vaccine. Conclusions: There is paucity of knowledge of the risk factors of cervical cancer among the study participants. To improve the knowledge, we advocated for awareness campaigns and affordable cervical cancer screening services. Keywords: Cervical screening, Demographic factors, HPV vaccination, Nigeria

2024-07-03T00:00:00Z EKEDIGWE, J.E ONUBI, J ELISHA, A ESEIGBE, P AMAKU, C CHIMA, AAG http://localhost:8080/xmlui/handle/123456789/2771 2024-09-12T12:55:59Z 2024-07-01T00:00:00Z

Digital Radiographic Rejection Analysis in a Tertiary Hospital in North Central Nigeria EKEDIGWE, J.E; ONUBI, J; ELISHA, A; ESEIGBE, P; AMAKU, C; CHIMA, AAG Radiographic imaging is an essential tool in modern medicine, providing critical diagnostic information. However, the quality of these images can be compromised by various factors leading to rejection, which in turn affects patient management and increases healthcare costs. The findings from this study will be used in planning and implementing improved diagnostic accuracy, reducing the operational burden and cost on healthcare facilities. This study investigates the rejection rate of digital radiographs in a tertiary hospital in North Central Nigeria, aiming to identify common causes and distribution patterns by body part, sex, and age. A comprehensive retrospective analysis of 299 radiographic examinations over a period of 6 months was carried out by a certified radiologist. The study revealed a rejection rate of 10.37%. The most frequent reasons for rejection included poor positioning, incomplete images, and cut-off errors. The study also found slight variations in rejection rates between males and females and between children and adults. Notably, the chest radiographs exhibited the highest rejection rate, primarily due to positioning issues. These findings underscore the need for improved training and quality control measures to enhance the overall quality of radiographic imaging and patient care.

2024-07-01T00:00:00Z Abriba, Simon P. Gamde, Solomom M. Ogidiagba S. M., Stephanie M. http://localhost:8080/xmlui/handle/123456789/2770 2024-09-12T12:50:59Z 2024-07-03T00:00:00Z

Decoding the Natural Killer Cell Enigma: A Review Abriba, Simon P.; Gamde, Solomom M.; Ogidiagba S. M., Stephanie M. Background: While the liver’s hepatocytes and Kupffer cells are prominent foci of study, the distinct and relatively uncharted roles played by the natural killer cells in liver immunity provide fertile ground for exploration. In this review paper, we have tried to uncover the unique phenotypic and functional attributes of liver-resident natural killer cells, consequently establishing a profound connection between liver immunology and histopathology. Objective: This review aims to provide an overview of the phenotypic and functional properties of the liver-resident natural killer cells, giving insight on the immunological and histological repercussions of their interactions during liver infections, inflammation, and hepatocellular cancer. Methods: In this review, published papers in electronic databases comprising PubMed, Scopus, and Google Scholar were retrieved using search themes such as immunological cells, natural killer cell, liver inflammation, and liver cell were examined. Results: The liver-resident natural killer cells are potent producers of cytokines, including interferon-gamma (IFN-γ) and modulate the phenotype and function of hepatic macrophages, enhancing their antimicrobial activity, as well as influence the activation and cytotoxic function of CD8+ T cells, particularly during chronic liver inflammation. Conclusion: Our review underscores the undeniable significance of the natural killer cells in the liver defence and highlighted the challenges and constraints researchers encounter when studying the liver natural killer cells. Continued research endeavour are necessary to harness the full capabilities of the natural killer cells, ultimately leading to better insights, innovative therapies, and enhanced protection for the liver, and by extension, the entire body.

2024-07-03T00:00:00Z