Published Journal Articles from the department. http://localhost:8080/xmlui/handle/123456789/224 2026-04-05T21:30:27Z 2026-04-05T21:30:27Z Onubi, Jeremiah http://localhost:8080/xmlui/handle/123456789/2838 2024-09-22T09:05:10Z 2024-09-06T00:00:00Z

Sociodemographic Factors Associated with Depression among People Living with Human Immunodeficiency Virus on Antiretroviral Therapy at a University Teaching Hospital in a Nigerian Cosmopolitan City Onubi, Jeremiah Background and objectives: Depression can lead to poor outcomes during antiretroviral therapy, and current evidence suggests high rates of depression among people living with human immunodeficiency virus (PLHIV), especially in low-and middle- income countries. This study was designed to investigate the sociodemographic factors associated with depression among PLHIV on antiretroviral therapy in a Nigerian cosmopolitan city. Methods: A hospital-based, cross-sectional study was conducted among 592 consenting, randomly selected adult PLHIV receiving treatment at a university teaching hospital in Jos, Nigeria, in 2022, using the PHQ-9 questionnaire and an intervieweradministered sociodemographic questionnaire. Associated variables in univariate analysis were used in multivariable binary logistic regression to obtain adjusted odds ratios (AOR) with a significance level set at α = 0.05. Results: Depression was found to be highly prevalent among study participants, with 44.9% of them affected. Findings revealed that being male [AOR = 0.62; 95% confidence interval (CI): 0.42–0.92], being employed (AOR = 0.55; 95%CI: 0.31–0.97), and earning a monthly income of ₦50,000–100,000 ($65–130) (AOR = 0.49; 95% CI: 0.27–0.91) and >₦100,000–200,000(>$130– 260) (AOR = 0.33; 95% CI: 0.13–0.77) were significantly associated with reduced odds of depression. Conclusions: The significant association of being male, having formal employment, and earning a moderate monthly income with reduced odds of depression may have implications for policy and strategies for managing mental health issues among PLHIV in cosmopolitan areas like Jos, which face peculiar challenges such as cultural tensions, traffic congestion, and gentrification. PLHIV categories with a relatively higher likelihood of depression may benefit from targeted mental health support systems, in addition to other mental health management strategies generally available to PLHIV.

2024-09-06T00:00:00Z Onubi, Jeremiah http://localhost:8080/xmlui/handle/123456789/2837 2024-09-22T09:03:56Z 2024-08-01T00:00:00Z

Levels and Predictors of Unsuppressed Viremia among People Living with HIV on ART in an Urban Population of North-Central Nigeria: A Retrospective Cross-sectional Study Onubi, Jeremiah Achieving viral suppression is crucial for the effective management of HIV. We investigated the prevalence and predictors of unsuppressed viremia among adults living with HIV (PLHIV) on antiretroviral therapy (ART) in the urban city of Jos, Plateau State, North-central Nigeria. A cross-sectional study was conducted with 2,748 PLHIV, comprising 1,902 females (69.2%) and 846 males (30.8%). The majority (71.0%) were aged 36-55 years. Most participants (88.1%) were on the first-line ART regimen tenofovir disoproxil fumarate-lamivudine-dolutegravir (TDF+3TC+DTG), with 6.0% on second-line regimens. The prevalence of unsuppressed viremia (viral load >1,000 copies/mL) was assessed, and predictors were identified using chi-square tests and logistic regression analyses. Overall prevalence of unsuppressed viremia was 4.0% (110 participants), with higher proportions among males (5.6%) compared to females (3.3%) and among those aged 18-35 years (7.9%) compared to other age groups. PLHIV on first-line TDF+3TC+DTG ART had the lowest level of unsuppressed viremia (2.6%). Chi-square tests revealed significant associations between unsuppressed viremia and gender (χ2=7.67, p=0.01), age group (χ2=13.19, p=0.01), and ART regimen (χ2=110.97, p=0.0001). Multivariate logistic regression identified males (AOR=1.69; 95% CI: 1.12-2.56), younger age groups (18-35 years: AOR=12.96; 95% CI: 2.12-79.09 and 36-45 years: AOR=12.84; 95% CI: 3.70-44.64), and non-TDF+3TC+DTG regimens as significant predictors of unsuppressed viremia. The study highlights the effectiveness of the TDF+3TC+DTG regimen and the need for targeted interventions to address disparities in viral suppression, particularly among males and younger individuals. These findings are crucial for optimizing HIV treatment strategies and improving health outcomes for PLHIV in urban areas of low-and-middle-income countries.

2024-08-01T00:00:00Z Onubi, Jeremiah http://localhost:8080/xmlui/handle/123456789/2836 2024-09-22T09:03:03Z 2023-12-01T00:00:00Z

Seroprevalence of Hepatitis B and C Virus Infections among Healthcare Seekers at a Tertiary Health Facility in North-Central Nigeria: A Retrospective Study Onubi, Jeremiah BACKGROUND: Hepatitis B and C viral infections are among the common infectious diseases with global public health dmpottance. Nigeria is among the countries identified to be hyper-endemic for hepatitis B virus (HBV) infection. This study aimed to determine the seroprevalence of HBV and hepatitis C virus (HCV) infections among healthcare seekers at Bingham University Teaching Hospital, Jos, Nigeria, to increase awareness among the populace and sensitize public health stakeholders. METHODS: A retrospective study that involved data abstraction from the medical laboratory records of patients seeking care at Bingham University Teaching Hospital. The information collected included screening result for HBsAg and anti-HCV. Data were analyzed using SPSS version 24. RESULTS: A total of 186 patients were screened for HBV infection and 96 were screened for HCV infection. The mean ages and standard deviations were 36.2 + 15.05 years and 37.2 ± 14.48 years for those screened for HBV and HCV, respectively. The seroprevalence rate of HBV infection was 14.0% while the rate for HCV infection was 10.4%. Males had a higher HBV seroprevalence of 9.1% than females with 4.9%. For HCV seroprevalence, females recorded a higher prevalence of 6.2% compared to their male counterparts who had 4.2%. Among those screened for HBV, the young adult age group had the highest prevalence rate of 10.2%, while for the HCV screen the middle-aged group had the highest prevalence rate of 6.2%. These were, however, not statistically significant (p > 0.05). CONCLUSION: This study has shown that both HBV and HCV infections are hyper-endemic. There is a need to intensify awareness campaigns and improve the implementation of preventive and management strategies for HBV and HCV infections.

2023-12-01T00:00:00Z Onubi, Jeremiah http://localhost:8080/xmlui/handle/123456789/2800 2024-09-19T10:58:07Z 2023-09-01T00:00:00Z

Prevalence and Experience with Ureteric Fistula in a Comprehensive Obstetric Fistulae Care Facility in Jos North- Central Nigeria; Onubi, Jeremiah Urinary incontinence resulting from genital fistulae has been on the increase for over a decade now due to increased fistula care and treatment awareness and improvement in access to care and treatment coupled with community awareness program in which care and treatment: intervention are now made possible close to where the sufferers of fistulae live. A study carried out in our facility in 2007 showed an annua) fistulae case of about 300, while we currently diagnose between 400 and 500 cases annually. Besides vesicovaginal fistula (WF) which is the commonest female genital fistula, ureterovaginal fiitula (UVF) appears to also be on the increase. We therefore carried out a review of the diagnosis and surgical outcomes of ureteric fistulae in order to ascertain the proportion of the female genital fistulae that are version 26.0ver the period of review, 2445 fistulae cases were diagnosed out of which 103 were ureteric fistulae/uretero-vag nal fistula (UVF) giving us a prevalence of 4.2%. The leading aetiological factors Myomectomy 13 (12.6% of 103) and congenital 9 (8.7% of 103). The surgical success rate was 98.1% both at 3 and 6 mmths post-surgical repair. From the study, Caesarean delivery is a common procedure in obstetric and delivery practice after vaginal delivery and was responsible Ureterovaginal fistulae have become a the left ureter affected more than the r 103 cases and less morbidity recorded is a reflection of surgical competency and efficiency of the Fistulae care and treatment team at the centre. Keywords: Evangel VVF centre. Fistula, Iblorth central Nigeria, Ureteric, Uretero-vaginal- fistula :

2023-09-01T00:00:00Z