http://localhost:8080/xmlui/handle/123456789/35 2026-04-05T21:22:59Z 2026-04-05T21:22:59Z MAKANJUOLA, Victor O. http://localhost:8080/xmlui/handle/123456789/2328 2024-06-25T15:31:13Z 2014-07-09T00:00:00Z

Effects of ethanol extract of Dissotis rutundifolia on the histology of the ovary, uterus and Gonadotropins of adult female Whistar rats. MAKANJUOLA, Victor O. This study was aimed at evaluating the effects of ethanol extract of Dissotis rutundifolia on the histology of the ovary and uterus of Adult whistar rats. A total of twenty (20) wister rats weighing 150- 180g were used in this experiment and were divided into 5 groups (1-5) of 4 rats per group. Group 1(control) were administered 2ml distill water, group 2 (low dose) received 25mg/kg bw daily, group 3 (low dose + withdrawal) 25mg/kgbw, group 4(high dose) received 100mg/kgbw while group 5 received (high dose + withdrawal received) 100mg/kgbw. the extracts was administered by gavage once daily for 14 days in all treated groups while in group 3 and 5 there was withdrawal for seven days. At the end of treatment the rats were sacrificed and the Ovary and Uterus harvested and histologically processed and stained using H&E stains while blood samples was obtained intraoccularly for hormonal assay all groups. The histological results showed a loss in follicles production and an increase in atretic follicles in ovaries in ovaries with loss of endometrial and glandular cells in the uterus. There was a significant decrease in serum levels of follicle stimulating hormone (FSH) and Luteinizing hormones (LH) with prolonged dioestrous stage as compared to the normal control group. In the withdrawal groups normal ostrous cycle was observed with production of ovarian primary follicles, restoration of uterine endometrium and glandular cells. The level of FSH and LH was also restored.

2014-07-09T00:00:00Z MAKANJUOLA, Victor O. http://localhost:8080/xmlui/handle/123456789/2327 2024-06-25T15:21:14Z 2007-01-01T00:00:00Z

Profertility Effects Of Alcoholic Extract Of Sesame In Male Sprague-Dawley Rats MAKANJUOLA, Victor O. The effects of administration of ethanolic extract of sesame and Vitamin C as adjuvant on the reproductive system of male sprague-Dawley rats were exploited in this work. 20 rats were randomized into four groups (Control, T1, T2, T3) of 5 rats each. One of the group serves as control group while the other 3 groups received a sub-lethal dose of sesame extract (3000mg/kg body weight) once in a day for 8 weeks. One of the treatment groups (T3) also received 2.5mg/kg of Vitamin C for 8 weeks. At the end of the 8 weeks, animals in Control, T1 and T3 were sacrificed while T2 was withdrawn from extract administration for 4 weeks to test for the effect of withdrawal. Sperm counts, Morphology and Motility were quantified and organ and general body weights were measured in a weighing balance. Results of the experiment revealed an increment in the sperm count and sperm percentage motility but a decreased percentage morphology distortion. There were dose-dependent increments in body and organ weight gains, withdrawal notwithstanding. This experiment thus revealed that ethanolic extract of sesame seed possesses potent profertility properties which may be beneficial to those who consume it.

2007-01-01T00:00:00Z MAKANJUOLA, Victor O. http://localhost:8080/xmlui/handle/123456789/2325 2024-06-25T15:02:43Z 2010-07-24T00:00:00Z

Effects of administration of ethanolic roots extract of jathropha gossypifolia and prednisolone on the kidneys of wistar rats MAKANJUOLA, Victor O. The effect of oral administration of ethanolic root extract of Jatropha gossypifolia and prednisolone on the kidney histology and renal function of albino rats was studied to assess the safety and toxicity of the plant as an herbal remedy. The rats were divided into four groups I, II, III and IV. Group I served as control and was given feed and water only. Group II, III, and IV were subdivided into Group IIa, IIb, IIIa, IIIb, IVa and IVb. Groups IIa, IIIa, and IVa received 10 mg, 20 mg and 30 mg/kg b.w of the extract while Group IIb, IIIb and IVb received 10 mg ,20 mg and 30 mg/kg b.w of the extract respectively plus 10 mg/kg b.w of prednisolone per day. The animals were sacrificed on day 7, 10 and 14 and their kidneys harvested and processed for histological studies. Their blood was also collected for serum urea measurement. Photomicrographs of the histological sections of Groups II, III and IV rats revealed changes compared to the control group and serum urea levels were significantly higher in these groups. Histological changes observed are consistent with glomerulonephritis and include increased urinary (Bowman's) space, shrinkage and distortion of the glomerular tuft as well as scarring of the glomeruli. Changes appear to be both dosage and time dependent and the administration of prednisolone as an adjunct did not exert any ameliorative effect. We conclude that ethanolic root extract of Jatropha gossypifolia is toxic to the kidney and causes increased urea retention in the blood.

2010-07-24T00:00:00Z MAKANJUOLA, Victor O. http://localhost:8080/xmlui/handle/123456789/2313 2024-06-25T13:06:23Z 2012-01-01T00:00:00Z

Histological Integrity of The Testis of Adult Wistar Rats (Rattus Novergicus) Treated with Garcina Kola MAKANJUOLA, Victor O. Garcinia kola has been confirmed for spermatogenic and tissue enhancing effect of testis in male wistar rats. This study was carried out to investigate the histological effect of ethanolic extract of Garcinia kola on Lead II oxide induced testicular damage. Thirty five (35) adult male wistar rats were randomly selected into seven (7) groups n=5. Group A received 0.5 ml saline solution, Group B received 100 mg/kg of Garcinia kola extract only, Group C received 5 mg/kg of Lead II oxide only, Group D1 received 100 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group D2 received 200 mg/kg of Garcinia kola extract and 5 mg/kg of Lead II oxide, Group E received 500 mg/kg of vitamin E only and Group F received 500 mg/kg of vitamin E and 5 mg/kg Lead II oxide. Administration was done orogastrically daily for 2 weeks, animals were sacrificed 24 hours after the last administration by cervical dislocation and the testes excised following abdominal incision for histological observation using H/E stain. Slight degeneration of the germinal epithelium of the seminiferous tubule and abnormal widening of the interstitial space involving loss of Leydig were observed following the administration of Lead II oxide. However, Improvements in the testicular architecture were noticed in the rats treated with the Garcinia kola and the Vitamin E respectively thus histological integrity maintained.

2012-01-01T00:00:00Z