http://localhost:8080/xmlui/handle/123456789/613 2026-04-05T22:59:57Z 2026-04-05T22:59:57Z Mbah, Ikechukwu http://localhost:8080/xmlui/handle/123456789/2540 2024-07-08T20:23:03Z 2023-08-09T00:00:00Z

Prevalence and distribution of primary glomerular diseases in Africa: a systematic review and meta analysis of observational studie Mbah, Ikechukwu Glomerulonephritis (GN) is a predominant cause of kidney failure in Africa. The prevalence of primary GNs varies widely across Africa depending on the relative proportion of secondary GNs and genetic predispositions. We assessed the overall and sub regional prevalence of primary GN and its histologic subtypes in Africa. We searched PubMed, EMBASE and African Journals Online for studies of biopsy proven primary GNs across all age groups in Africa published between 2010 and 2022. Data for primary GNs [minimal change disease (MCD), focal segmental glomerulosclerosis (FSGS), membranous nephropathy (MN), mesangioproliferative GN (MesPGN), membranoproliferative GN (MPGN), post-infectious GN (PIGN), IgA Nephropathy (IgAN), and crescentic GN (CresGN)] were extracted. Pooled prevalence was determined using the random effects model. Seventeen eligible articles (n = 6,494 individuals) from 8 African countries met the inclusion criteria. The overall pooled prevalence of FSGS, MCD, MN, MPGN, MesPGN, PIGN, IgAN and CresGN was 26.10%, 22.40%, 8.40%, 6.40%, 6.40%, 2.60%, 2.60%, 1.40%, respectively. Only 4 studies (23.5%) used light microscopy (LM), immunofluorescence (IF), and electron microscopy (EM) for diagnosis. There were significant differences in the distribution of histologic subtypes in the paediatric compared to the adult population and across geographic sub-regions, with West Africa having a higher prevalence of FSGS. Overall, the dominance of FSGS across most regions and age groups has implications for disease diagnosis and ongoing care. Research efforts to understand the impact of this trend on kidney disease outcomes and efforts to improve kidney biopsy practice as a means of early disease detection are needed in African Systemic Review and Meta-analysis

2023-08-09T00:00:00Z Mbah, Ikechukwu http://localhost:8080/xmlui/handle/123456789/2539 2024-07-08T20:21:27Z 2019-10-22T00:00:00Z

Pattern of non-communicable diseases seen in a tertiary hospital in Keffi, North Central Nigeria Mbah, Ikechukwu Background: The burden of noncommunicable diseases(NCDs) is increasing in developing countries largely due to epidemiological transition. In this study, data of individuals who were seen in specialist medical clinics and wards in a hospital located in a fast-growing urban area were analyzed to identify the pattern of NCDs among the attendees. Materials and Methods: A retrospective study of available registers and electronic medical records of adult patients with diagnoses of medical disorders seen between January 2006 and January 2016 at the specialist medical outpatient clinics and medical, emergency, and intensive care wards of Federal Medical Centre, Keffi, Nasarawa State, Nigeria, was carried out between January 2015 and January 2016. Medical records of 682 individuals were reviewed, and their data were extracted and analyzed. Results: Females(59.1%) and people in the middle-age group (44.6%) constituted majority of adult participants who were seen in the facility for medical diseases. The prevalence of NCDs was 64.4%, with cardiovascular disease (CVD) being the most common (37.7%). Hypertension was the most prevalent CVD (70%). Conclusion: NCDs were the predominant diseases seen at the specialist clinics and medical wards in the study. CVDs were the most prevalent NCDs followed by endocrine diseases. Original Article

2019-10-22T00:00:00Z Nkpozi, MO, IO, GE, K, C, FA Mbah. , Bozimo, Akhidue. Ezeude, Owolabi Nkpozi Mbah., MO, IO, GE, K, C, FA MO, IO, GE, K, C, FA Bozimo, Akhidue. Ezeude, Owolabi http://localhost:8080/xmlui/handle/123456789/2538 2024-07-08T20:17:31Z 2024-02-16T00:00:00Z

Obesity and hypoglycaemia in type 2 diabetes mellitus outpatients on insulin therapy in Nigeria–data from the multicentre evaluation of type 2 diabetes mellitus outpatients patients on insulin therapy. METOIN Study Nkpozi, MO, IO, GE, K, C, FA Mbah. , Bozimo, Akhidue. Ezeude, Owolabi; Nkpozi Mbah., MO, IO, GE, K, C, FA MO, IO, GE, K, C, FA Bozimo, Akhidue. Ezeude, Owolabi Background and Objective: Despite the obvious benefits of early insulin use in achieving good glycaemic control, insulin linked overweight/obesity and hypoglycaemia are sources of concern and worry. Burden of these side effects among type 2 diabetes mellitus (T2DM) outpatients on insulin therapy in Nigeria is unknown. Subjects and Methods: This was a prospective, cross sectional and observational study in which consenting T2DM outpatients that meet the inclusion criteria for the study in five tertiary health facilities were simultaneously recruited and relevant data obtained via investigator-administered questionnaire. Data obtained which included gender, arthropometric measures, hypoglycaemia and where it was treated were analyzed using Statistical Package for Social Sciences (SPSS) version 23.0 software. Results: A total of 245 T2DM outpatients were recruited into the study, made up of 107 (43.7%) male and 138 (56.3%) female. Of this, 121 (49.8%) patients were overweight while 70 (28.7%) were obese. Among the patients, 104 (42.4%) T2DM outpatients on insulin therapy reported hypoglycaemia which was mild in 83 (79.8%) of the patients Conclusion: A significant number of the type 2 DM outpatients on insulin therapy were overweight/obese with mild hypoglycaemia in a majority of them.

2024-02-16T00:00:00Z MBAH, I O http://localhost:8080/xmlui/handle/123456789/2461 2024-07-02T14:35:03Z 2006-01-01T00:00:00Z

The Relationship between Metabolic syndrome and Progressive renal disease: The Zankli Experience MBAH, I O

2006-01-01T00:00:00Z