http://localhost:8080/xmlui/handle/123456789/348 Conference Papers from the department. 2026-04-05T19:47:17Z http://localhost:8080/xmlui/handle/123456789/2368 Haemato-Biochemical Effect of Combined Ginger (Zingiber Officinale) and Garlic (Allium Sativum) in Female Wistar Rats ISHAKU, Sheba John; TORYILA, Joseph Emberga medicinal properties incuding antioxidant, anti-inflammatory, antimicrobial, analgesic, immunity booster, anti- diabetic, regulation of blood pressure and treatment of cardiovascular diseases. The study was designed to in vestigate the separate and combined effects of garlic (Allium sativum) and ginger (Zingiber officinale) on haemato- biochemical parameters in Wistar rats. METHODOLOGY: Twenty (20) female wistar rats were used, the rats were divided into four groups of five rats each: Group 1: (Control); Group 2 was administered 5g/kg of ginger, Group 3 was administered 5g/kg garlic and Group 4was administered ginger 5g/kg and garlic Sg/kg.AU administration was via oral route for four (4) weeks. RESULTS: The results showed a significant increased bleeding time and clotting time(p<0.05) and decreased platelet count in group 4 administered combined doses of ginger (5g/kg) and garlic (5g/kg) extract when compared to the control group(p<0.05). There was a significantly increased serum AST activities in the group treated with 5g/kg ofgarlic only compared to that of the control (p<0.05). There was a significant increase in serum ALT in the group treated with 5g/kg of garlic only (p<0.05) and the ginger and garlic treated group when compared to the control group (p<O.OS).CONCLUS!ON: Co-administration of ginger and garlic to rats significantly increased bleeding and clotting time and decreased platelei count. There was significant change in activities of liver enzymes hence caution should be taken in consumption of combined ginger and garlic 2022-11-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/2367 Effect of Musa Paradisiaca (BANANA) Flour Supplement on the Reproductive System of Male Wistar Rats ISHAKU, Sheba John; TORYILA, Joseph Emberga Background: Infertility’ is a worldwide health concern in the developing world, affecting 8-15% of couples in their reproductive age. Musa paradisiaca (BANANA) is a crop in the genus Musa and all members of the genus are indigenous to tropical and subtropical countries. Banana is wildly consumed by Africans especially by Nigerians. The study was aimed at determining the effect of Musa paradisiaca (BANANA) flour supplement on the reproductive system of male wistar rats. Methodology': Twenty’ (20) male wistar rats weighing between 85-170g were usedfor this study and were randomly divided into four (4) groups. Group one served as the control, group 2 and 3 were treated with commercial feed supplemented with banana flour in the ratio 20:80 ratio and 5ml/kg of body weight of lime juice orally for four weeks. Group 4(Positive control) was given 5ml/kg body weight of lime juice orally for four weeks. The animals were sacrificed by cervical dislocation and semen samples were collected. Sperm motility, sperm morphology, sperm count and testosterone levels were investigated. Resuls: The result shows that there was increase in sperm motility’ in treated groups 2 (65.00±13.23) and 3 (68.33±7.64) compared to group 4 and the control group (60.0±20.0), significant increase (P< 0.05) in sperm count in treated groups 2 (2100.00±208.44) and 3 (2700.00±754.44) compared to group 4 and the control group (1933.33±120.43), There was a significant increase (P< 0.05) in sperm mortality’ in treated groups 2 and 3) compared to group 4 and the control group. There was a significant increase (P< 0.05) in testosterone level in treated groups 2 (5.73 ± 4.38) and 3 (7.56 ±5.07) compared to control the group (1.23 ±0.32). There was a significant increase in sperm abnormalities in group 4 (11.67±7.63) when compared to group 2,3 and the control (P** 0.05). Conclusion: The effect of banana flour supplement on the reproductive system of male wistar rats was investigated and it was shown to increase sperm motility, sperm count, testosterone levels in all treated groups, while decreasing sperm mortality and sperm abnormalities. 2022-10-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1740 The Effects of Jatropha Fanjorensis Aqueous Leaf Extract on Haematological Parameters in Wistar Rats TORYILA, Joseph ABSTRACT Immense benefits have been derived by man from using medicinal herbs in treatment and management of disease because they are relatively safer, more affordable and sometimes offer better therapeutic value than synthetic drugs. The leaves of Jatropha tanjorensis have been used for the treatment of diabetes mellitus. This study investigated the Haematological indices of aqueous leaf extract of Jatropha tanjorensis in male Wistar rats.25 male Wistar rats weighing 150-180g were used for the research. The rats were divided into five groups of five rats each. Group I served as control, and groups II, III, IV and V were administered 125mg, 250mg, 500mg, and 750mg per kilogram body weight respectively of the Jatropha tanjorensis leaf extract daily for 14 days. The rats were maintained under standard laboratory conditions at the animal house in the Faculty of Basic Medical Sciences, Bingham University, Nasarawa State The rats were sacrificed by cervical dislocation and blood collected by cardiac puncture. 2mls of blood were placed in EDTA bottle for the determination of haematological parameters using Auto Haematology Analyzer. The result shows significant increase in RBC, Hb, PCV, WBC, and PLT in the groups treated with 125mg/kg ,250 mg/kg and 500mg/kg aqueous leaf extract of Jatropha tanjorensis when compared with the control(P<0.05). However, at higher dose of 750mg/kg of aqueous leaf extract of Jatropha tanjorensis, there was a decrease in RBC, Hb, PCV, WBC, and PLT (P<0.05) when compared with the control. There were no statistically significant changes in MCV, MCH, MCHC, Monocytes, Eosinophils and Basophils in all treated groups compared to the control. Neutrophils was significantly decreased in group treated with 750mg/kg compared with control (P> 0.05). The results of this study indicated that at lower doses, the aqueous leaf extract of Jatropha tanjorensis leaves may enhance haemopoiesis, but administration of higher dosage may cause haemolysis 2019-12-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/1739 Platelet Counts and Mean Platelet Volume Amongst Elderly Nigerians TORYILA, Joseph ABSTRACT The study was conducted in Zaria, Nigeria aimed at determining reference values of Platelet Counts, Mean Platelet Volume and the relationship between the Platelet Count and Mean Platelet Volume. These parameters were determined from 400 healthy elderly subjects comprising 210 males and 190 females. with a mean age of 69.4±7.9 years . 400 young adults were used as control comprising 200 males and females respectively with a mean age of 24.1 ±4.2years. Healthy elderly adults had a mean platelet count of 161.8±3.0 X 109/L and 214.5±3.1 X 109/Lin males and females respectively. Sex and age differences in platelet counts were observed in the elderly subjects (P < 0.05). The mean (SEM) for mean platelet volume for healthy elderly males and females was 9.8±0.6 fl and 9.7±0.6 fl respectively. There was an inverse correlation between mean platelet volume and platelet counts (r = - 0.286, P < 0.05). Platelet count was lower in healthy elderly subjects compared to the young adults control (P < 0.05). The use of separate reference value of platelet count in the elderly is advocated. 2009-01-01T00:00:00Z