http://localhost:8080/xmlui/handle/123456789/589 Published Book Chapters from the department. 2026-04-06T00:36:43Z http://localhost:8080/xmlui/handle/123456789/653 Wound Care: Traditional African Medicine Approach BUILDERS, Philip F.; BUILDERS, Modupe I. Wound care represents a major health burden in Africa. The types and causes of wounds in Africa are numerous; however, the interventions to these injuries are easily accessed in hospitals in the urban cities, while in most rural communities, the primary source of interventions is traditional medicine (TM). In recent times, there are incidences of preferences to the use of TM in the management of especially challenging wounds even when conventional interventions are available. In some African communities, there are incidences of quasi integration of conventional and traditional African medicine (TAM) in wound care. In the typical traditional African approach to wound care, diverse practices such as the use of herbal medicine, divination, and other physical interventions are common. There appears to be a favorable future for wound management using TAM with the increasing popularity due to various affirmative reasons other than poverty. The recognition, patronage, and uses of TAM for wound care as an alternative or complimentary to the conventional approach is expected to continue, hence, the need for the different regional governments in consonance with the WHO to promote the standardization, regulation, and other factors that will assure the safety and efficacy of the various practices and products of TAM. 2016-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/652 Toxicity Studies of the Extracts of Parkia biglobosa Stem Bark in Rats BUILDERS, Modupe I.; ISICHIE, C. O.; AGUIYI, J. C. Extracts of Parkia biglobosa stem bark is used in Nigerian traditional medicine (NTM) to treat malaria, diarrhea and pains. To establish the toxicity profile of the medicine such parameters as the lethal dose (LD50) as well as effects on body functions and organs were evaluated in albino Wistar rats. The bioactive constituents of the water and methanol extracts were also evaluated as a link to toxicity. The LD50 was greater than 5000mg/kg per oral (p.o) for both extracts. No significant (P< 0.05) changes in body weights and vital organs of treated animals. However, at 5000mg/kg of water extract, a significant increase in relative weight of the kidneys and hyper -cholesterolemic effects were observed. The extract also elicited significant increase in blood glucose level. The kidneys and livers of animals treated with P. biglobosa water extract for 14 days revealed histopathological evidence of pathological lesions. The methanol extract did not show any changes in the levels of hepatic and hematological parameters, histopathological evidence of pathological lesions, and serum level of urea, uric acid, bilirubin, creatinine and total protein concentrations. Treatment elicited hypo - cholesterolemic effects and significant reduction in blood glucose level occurred in all the groups. The phytochemical screening revealed the presence of tannins, flavonoids, saponins, terpenes, cardiac glycosides, phenols and reducing sugars in the methanol extract, the water extract showed the presence of similar constituents with the absence of flavonoids and cardiac glycosides. This study has shown the toxicity characteristics of the methanol and water extracts of the stem bark P. biglobosa in short time treatment with the extracts. This study has shown the diversity in toxicity as well as the chemical constituent of the stem barks of P. biglobosa in relation to the extraction solvent. However this study provides the basis for further study on the detailed toxic and pharmacological effects of the extracts of P. biglobosa stem bark and their active component(s). 2019-01-01T00:00:00Z http://localhost:8080/xmlui/handle/123456789/651 Assessment of Antimalarial Drug Use among the Patients in a Tertiary Hospital in Northern Part of Nigeria BUILDERS, Modupe I.; OGBOLE, Emmanuel; PETER, Jonah Y. Aims: To assess the pattern of antimalarial drug use among the patients attending the teaching hospital in Jos North local Government of Nigeria. Study Design: Cross-sectional study. Place and Duration of Study: Tertiary hospital in Jos North Local Government of Plateau state of Nigeria, between July and September, 2012. Methodology: A sample size of 441 male and female patients was selected into this study using a universal sampling. Information on the knowledge, attitudes and practices with respect to antimalarial drug use were obtained with the aid of a pre-tested interviewer-administered questionnaire. Data was analyzed using the SPSS software. Results: Four hundred and forty one (441) patients completed the questionnaire. Respondent knowledge of malaria with respect to description of malaria decreased (42.7% to 0.2%). Almost all the patients were able to describe the causes and symptoms of malaria. One hundred and sixty nine (38.3%) frequently treated their malaria with Sulphadoxine-Pyrimethamine (SP) combination, Three hundred and eighty two (86.6%) reported to have used oral preparation, almost half of the respondents (47.6%) obtained these medications from many sources apart from hospitals, only two hundred and forty eight reported to comply to treatment. Majority of the participants always used some methods for the prevention of malaria. Conclusion: Concerted effort should be made to educate the population on malaria as well as the importance of drug adherence. Provision of ACTs at subsidized costs will go a long way in improving malaria treatment services in Nigeria, indigenous plantations for cultivating active ingredients and local manufacturing of ACTs is further expected to lower the costs of the drugs and increase its utilization and lower the incidence and impact of malaria. It will be important for interventions to be directed at educating the consumers on malaria pathogenesis, diagnosis, therapy and prevention and importance of drug adherence in order to improve the quality, efficacy of treatments and to reduce local morbidity and mortality in the future. 2019-01-01T00:00:00Z